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Neurology Skip to main page content Celebrating 60 Years of Publication Visit www.aan.com * Home * Browse Topics * WriteClick * Current Issue * Patients * CME * Residents & Fellows Quick Search keyword _____________________ author _____________________ year _____________________ volume _____________________ page _____________________ SearchAdvanced Search [ Search ] * Login * Help * Feedback Advertisement * Download the New Neurology App for iPad(R) WriteClick(TM): Rapid Online Correspondence - Join the Debate Now! In Focus Spotlight on the November 8 Issue Robert A. Gross, MD, PhD Editor-in-Chief Second issue of Neurology: Clinical Practice Transient ischemic attacks characterized by RNA profiles in blood RNA expression in blood of patients with transient ischemic attacks (TIAs) was compared to that of vascular risk-factor control subjects without symptomatic cardiovascular disease. There were 480 probe sets, corresponding to 449 genes. The 2 gene expression profiles associated with TIAs may help to identify patients at high risk for stroke. See p. 1718 From editorialists Cucchiara & Nyquist: In this issue of Neurology, Zhan et al. report a small study examining gene expression profiles in the blood of patients with acute TIA . . .. The results . . . give reason for hope, but also suggest that the path forward will be long, complex, and challenging. See p. 1716 Hyperacute injury marker (HARM) in primary hemorrhage: A distinct form of CNS barrier disruption The authors evaluated MRIs from patients admitted with acute intracerebral hemorrhage for the presence of postcontrast sulcal enhancement on FLAIR sequences. Eighty-five percent showed some degree of barrier disruption, with one-half being moderate to severe. Hyperacute injury markers may be useful to test therapies aimed at stabilizing acute blood barrier disruption. See p. 1725 Vascular risk factors and cognitive impairment in a stroke-free cohort Cognitive function was measured annually in a sample of adults aged 45 years and older, followed for 4 years. More than 1,900 cases of new cognitive impairment were identified. Vascular risk factors, including presence of left ventricular hypertrophy and high systolic blood pressure, may provide the means of identifying adults at risk for cognitive impairment. See p. 1729 Neuropathologic features associated with Alzheimer disease diagnosis: Age matters In an analysis of 2,014 older adults, the relationship between clinical AD diagnosis and neurofibrillary tangles was attenuated among the oldest old compared to the young old. Neuropathologic features did not differentiate as well among people in this age group without a clinical AD diagnosis. See p. 1737 SPECIAL ARTICLE Evidence-based guideline update: Treatment of essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology podcast icon cme icon A literature review using MEDLINE, EMBASE, Science Citation Index, and CINAHL was performed to identify clinical trials in patients with essential tremor published between 2004 and April 2009. Controlled clinical trials of additional medications for tremor using standardized outcome measures are needed. See p. 1752 VIEWS & REVIEWS Parkinson disease: The enteric nervous system spills its guts This review outlines evidence that the enteric nervous system (ENS) is affected by Parkinson disease pathology. Routine colonic biopsies will allow the identification of Lewy pathology in the ENS of patients with Parkinson disease.See p. 1761 NB: 'The seagull cry' in internal carotid artery dissection, see page 1769. To check out other NeuroImages, point your browser to www.neurology.org. 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Press Room AAN Guidelines Neurology Podcasts(TM) Neurology& Podcast Cover Download Latest Issue Subscribe Now NEW CME Opportunity: Listen to this week's Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits by answering the multiple-choice questions in the online Podcast Quiz This Week's Podcast This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discusses highlighted articles from the November 1 issue. In the second segment Dr. Jennie Taylor interviews Dr. Josep Dalmau about his paper on Ophelia syndrome. In the next segment, Dr. Jennifer Fugate is reading our e-Pearl of the week about 'How long must an athlete wait before returning to play after a concussion'? In the next part of the podcast Dr. Ted Burns interviews Dr. Eelco Wijdicks about operational issues related to post-cardiac arrest patients. Over the following weeks, Dr. Burns will interview Dr. Wijdicks about neurologic evaluation of the post-cardiac arrest patient. Disclosures * The participants had nothing to disclose except Drs. Dalmau, Fugate, Burns and Wijdicks. Dr. Dalmau serves on the editorial board of Neurology; receives royalties from the editorial board of Up-To-Date; has filed a patent application for the use of LGI1 as a diagnostic test; has received royalties from Athena Diagnostics, Inc. for a patent re: Ma2 autoantibody test and has patents pending re: NMDA and GABAB receptor autoantibody tests (license fee payments received from EUROIMMUN AG); and receives research support from funding from EUROIMMUN AG, the NIH/NCI, and a McKnight Neuroscience of Brain Disorders award. Dr. Fugate serves on the editorial team for the Neurology Resident and Fellow Section. Dr. Burns serves as Podcast Editor for Neurology; performs EMG studies in his neuromuscular practice (30% effort); and has received research support from the Myasthenia Gravis Foundation of America and Knopp Neurosciences Inc.. Dr. Wijdicks serves as Editor-in-Chief for Neurocritical Care; and receives royalties for books published by Oxford University Press. * Advertisement HighWire Press Logo * Home * Browse Topics * Residents & Fellows * Current Issue * Patients * CME * WriteClick * International * AAN.com Copyright (c) 2011 by AAN Enterprises, Inc. * Print ISSN: 0028-3878 * Online ISSN: 1526-632X Lippincott Williams & Wilkins HighWire(R)